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Endocrine Abstracts

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ea0029s44.3 | Genome wide studies in reproduction | ICEECE2012

Genetics of (In)fertility

Laven J. , Stolk L. , Uitterllinden A.

Since menarche is the landmark for the beginning of fertility and menopause marks the end of a women’s reproductive lifespan genetics of fertility as well as infertility will be discussed taking recent GWAS data on both menarche and menopause into account.Recently, 30 new loci for age at menarche were identified in a meta-analysis of 32 genome-wide association studies (GWAS) in women of European descent. In addition to two known loci the new loci in...
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ea0026p517 | Bone/calcium/Vitamin D | ECE2011

Genome-wide association in the Rotterdam study implicates the 16q24 locus as determinant of osteoporotic vertebral fractures

Oei H L D W , Estrada K , Castano-Betancourt M C , van der Klift M , Kerkhof J M , Hofman A , Pols H A P , Stolk L , van Meurs J B , Zillikens M C , Uitterlinden A G , Rivadeneira F

Risk for vertebral fractures (VFx), the most common osteoporotic fractures, is a heritable complex trait. No genome-wide association studies (GWAS) searching for genetic susceptibility factors for VFx have been reported. We performed a GWAS for VFx in a population-based study of Dutch elderly. Thoracolumbar spine radiographs were scored for osteoporotic VFx using the McCloskey/Kanis method. Genetic data was available in 329 VFx cases and 2666 controls. We tested 2 543 887 impu...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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